Potential of ZnO Nanoparticles with Soursop Leaf Extract (Annona muricata L.) as Bioreductor for Antifungal Candida albicans Awil Endar Pramesti1, a), Siti Imroatul Maslikah1, b), Sri Rahayu Lestari1, and Aisy Hanifah1
1Department of Biology, Faculty of Mathematics and Science, Universitas Negeri Malang, Semarang Street 5, Malang City, East Java, Indonesia, 65112
Candidiasis is an infection caused by Candida albicans, a species that causes mucosal and systemic infections of the genitals, digestive tract, and respiratory tract. Treatment of candidiasis using antibiotics has side effects if used in the long term. Technological developments in the field of nanoparticles are very popular among researchers. This is because nanoparticles have a good ability compared to larger particles. The element of Zn in the form zinc oxide, is carried out by green synthesis in synthesizing nanoparticles by using plant extracts. Soursop leaf extract (Annona muricata L.) contains alkaloids, flavonoids, terpenoids, and tannins that act as bioreductants in the synthesis of metal nanoparticles. The purpose of this study was to analyze the potential and determine the most effective concentration of ZnO nanoparticles from soursop leaf extract as antifungal agents in C. albicans. This experimental study used complete randomized design with concentrations 0.1 mg/ml, 0.5 mg/ml, 1.0 mg/ml, 3.0 mg/ml, and 5.8 mg/ml. The antifungal activity test results stated that there was potential for ZnO nanoparticles from soursop leaf extract as antifungal agents in C. Albicans. The most effective concentration was found at a concentration of 3.0 mg/ml with an inhibition zone diameter of 14.38 + 0.42 mm.
