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The Potency of Apple Rose Leaf Ethanol Extract as a Natural Anthelmintic Universitas Islam Bandung and Universiti Kebangsaan Malaysia Abstract Infectious diseases of worms, are still a health problem with a high burden based on the incidence and mortality rates in Southeast Asian countries. Considering the high prevalence of worm sufferers in Southeast Asian countries, collaboration between researchers in the region of the country is needed. Indonesia and Malaysia, two countries in Southeast Asia that have close cultural affinities have the most opportunity to pioneer such cooperation and are expected to continue to develop into cooperation with other countries. The use of anthelmintics that can completely treat worm infections, namely worms and eggs is a necessity. The objectives of this study were: to evaluate the anthelmintic activity of worms and anti-worm eggs from apple rose leaf, to evaluate the potential of apple rose leaf to be developed as an anthelmintic which is effective in worms and worm eggs. The study was done with evaluated for anthelmintic activity on worms and eggs. Result showed that he ethanol extract caused a paralytic effect after contact with Ascaris suum for 90 minutes on male worms but had no effect on female worms for 120 minutes of observation. The ethyl acetate and water fractions had a paralytic effect after contact with Ascaris suum for 15 minutes and after 60 minutes of contact, all of the test worms experienced paralysis in both male and female worms. Java apple leaves also have an ovicidal effect. Ethanol extract significantly decreased the number of fertile eggs compared to control (p<0.05). The ability of apple rose leaf ethanol extract in inhibiting the development of fertile eggs was 78.87%. The apple rose leaves have the potential to be developed into natural anthelmintic suspension preparations. Keywords: apple rose leaf, natural anthelmintic, Ascaris suum Topic: Material Science |
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