The antidiabetic and antiplasmodium activities of prenylated xanthones from the stembarks of Garcinia parvifolia (Miq) Miq
Rini Muharini (ab*), Johanis Wairata (b), Yenni Pintauli Pasaribu (b)1, Theodore Y.K. Lulan (b), Taslim Ersam (b*)

a) Department of Chemistry Education, Faculty of Teacher
Training and Education, Univertas Tanjungpura, Pontianak, Indonesia
*rini.muharini[at]fkip.untan.ac.id
b) Laboratory of Natural Products and Synthesis,
Department of Chemistry, , Faculty of Science and Data
Analytics, Institute of Technology Sepuluh Nopember,
Surabaya, Indonesia

Abstract

Three prenylated xanthones, namely brasilixanthone B (1), latisxanthone A (2), and oliganthone B (3), together with stigmasterol (4), were succesfully isolated from stembarks of Garcinia parvifolia (Miq) Miq. Their structures were elucidated carefully using 1D and 2D NMR spectrocopy analyses, as well as comparinson with literature data. The isolated compounds were evaluated for their antidiabetic activities using alpha-amylase and alpha-glucosidase inhibitory assays. Compound 1-4 exhibited pronounce porcine pancreas alpha-amylase inhibition with IC50 values of 133.1, 5.9, 24.8, and 57.4 &#956-M, respectively. Moderate alpha-glucosidase inhibition were showed by compound 2 and 3. Meanwhile, compound 1 and 3 demonstrated potent antiplasmodium activity with IC50 values of 6.73 and 4.04 &#956-M against Plasmodium falciparum strain 3D7. It can be concluded that these prenylated xanthones from G. parvifolia (miq) Miq) have potential for apha-amylase, alpha-glucosidase, and Plasmodium falciparum inhibitors. This study was the first report of compound 1-3 from G. parvifolia (Miq) Miq.

Keywords: Prenylated xanthones- Baker^s yeast alpha-glucosidase assay- alpha-amylase assay- Garcinia parvifolia (Miq) Miq- Plasmodium falciparum

Topic: Natural Products and Biological Chemistry