Antiinflammation Drug Released Material Based on Chitosan/ Poly(Vinylpyrrolidone)/ Sodium Diclofenac Hydrogel Composites: Synthesis and Characterization
Yustika Desti Yolanda(a), Mita Nurhayati(a,b), Eli Hendrik Sanjaya(c), Murni Handayani(d), Fitri Khoerunnisa(a)*

(a) Graduate Program of Chemistry, Indonesia University of Education Setiabudi 229 Bandung 40154 Indonesia
(b) Department of Advanced Science and Technology Convergence, Kyungpook National University, Sangju-si, Gyeongsangbuk-do, South Korea
(c) Chemistry Department, Universitas Negeri Malang, 65145, Indonesia
(d) Research Center for Advanced Materials - National Research and Innovation Agency (BRIN), Kawasan Puspiptek, Tangerang Selatan, Banten, 15314, Indonesia

Abstract

Development of drug-controlled release material for biomedical applications has been carried out. This study aims to synthesis and characterization of chitosan/ poly (vinyl pyrrolidone)/sodium diclofenac-based hydrogel composites for antiinflammation drug delivery materials. The hydrogel composites were synthesized via solution mixing of polymer precursor solution with an aid of glutaraldehyde as crosslinker at room temperature. The composition ratio of each precursor and crosslinker was optimized systematically. In particular, the sodium diclofenac composition in hydrogel composite matrix was varied in order to investigated the drug release behavior in hydrogel composite. The synthesized hydrogel composites were characterized using several methods, i.e. FTIR spectroscopy, SEM-EDX, X-ray diffraction, TG/DTA, porosity, contact angle, swelling mechanical strength, and antibacterial tests. The results show that FTIR spectra confirmed the interaction of polymer precursors, crosslinker and drug compound that predominantly occurred via hydrogen bonding as indicated by typical absorption peaks at 3435 cm-1, 1650 cm-1, 1290 cm-1, and 600-800 cm-1. The SEM images at cross-section demonstrated the pore formation in hydrogel matrix as a result of crosslinker addition that well mixed with the polymeric matrix, indicating the three-dimensional network of hydrogel composites. Moreover, the swelling ratio, water contact angle and porosity of hydrogel composites were 3500%, 72.36 degree, 98.44%, respectively, that was obtained at optimum composition of polymeric precursors and crosslinker. These results inferred that the synthesized hydrogel composite has a hydrophilic nature and porous structure, consequently, demonstrated the large water absorption capacity as represented by huge swelling ratio. It also indicated that this composite has great potential as superabsorbent for drug release application. The other characterization results are still in progress.

Keywords: Hydrogel composites, Chitosan/PVP/sodium diclofenac, Antiinflammation, Synthesis, Characterization

Topic: Polymer Chemistry & Bio-based Materials