NiFe2O4-Hydroxyapatite Nanocomposite Synthesized Using Pensi Shells (Corbicula Moltkiana) as Hydroxyapatite Raw Material and Its Activity
Rahmayeni*, Yeni Setiadi

Universitas Andalas, Kampus Limau Manis

Abstract

\(NiFe_2 O_4 \)-hydroxyapatite (\(NiFe_2 O_4 \)-HA) nanopowders were synthesized hydrothermally using Piper betle L. extract as a capping agent and pensi (Corbicula moltkiana) shells as the raw material for hydroxyapatite. The powders were characterized by X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Scanning Microscopy Electron (FESEM), and Vibrating Sampler Magnetization (VSM). XRD pattern shows the specific peaks of hydroxyapatite that appeared at \(2 \theta \) of \(28.00^o\), \(32.42^o\), and \(34.34^o\) which are relevant to the standard of hydroxyapatite, and the specific peaks of \(NiFe_2 O_4 \) at \(2 \theta \) of \(30.2^o\), \(35.6^o\), and \(43.3^o\), which correspond to the ferrite spinel structure. Based on the FTIR spectrum, two main absorptions of metal and oxygen were found associated with the spinel ferrite structure at wave numbers of ~400 and ~600 \(cm^{-1} \). The \(M^{2+}\) ions are in the octahedral site, while the \(Fe^{3+}\) ions are in the tetrahedral site in the spinel structure. The results of FESEM characterization show the morphology of the nanocomposite in the form of granular evenly distributed. The synthesized nanoparticles showed ferrimagnetic properties as shown by VSM. The nanocomposite \(NiFe_2 O_4 \)-HA showed the percent effective drug release occurred in 3 hours at 81%.

Keywords: MFe2O4-HAp, Corbicula moltkiana, hydrothermal, ferrimagnetic, drug delivery

Topic: Inorganic Chemistry