Modification of Carbon Paste Electrode with Reduced Graphen Oxide for Voltammetric Analysis of Ibuprofen Levels
Muhammad Yudhistira Azis, Syahidah Muthmainnah, Henry Setiyanto

Analytical Chemistry Research Group 3rd Floor Department of Chemistry Jl. Ganesha No 10 Bandung 40133

Abstract

Ibuprofen is an anti-inflammatory drug commonly used to relieve symptoms of arthritis, fever, and as a pain reliever. The use of ibuprofen in excess of the dose (3200 mg per day) can cause digestive system disorders and the central nervous system. Therefore, its use should be limited and it is necessary to develop accurate analytical methods to identify ibuprofen in drug samples. One of the development methods of detection analysis which is cheap, fast response time, and simple procedure is voltammetry method. The development of a modified carbon-based working electrode with rGO is an alternative in the identification of drug compounds for voltammetric techniques. rGO is an electrically conductive material and its molecules can increase the sensitivity of the electrode in analyzing analytes with the same polarity. In this study, a method was developed for the analysis of ibuprofen by voltammetry using reduced graphene oxide modified carbon paste electrodes (EPK-rGO). Modifications were carried out by electrodeposition using graphene oxide 5% (w/v) in 0.1 \( Na_2 SO_4 \) M solution. Ibuprofen was measured using the square wave voltammetry (SWV) technique in acetate buffer solution pH 5. EPK-rGO has a linear region of 10 \( \mu M \) - 100 \( \mu M \) and 100 \( \mu M \) - 1000 \( \mu M \) with a detection limit of 2.6 \( \mu M \). Measurement of ibuprofen 20 times with EPK-rGO gave an RSD value of 2.82%. Scan rate analysis shows the electron transfer process is controlled by diffusion. Testing of interfering compounds with naproxen showed a ratio of naproxen: ibuprofen concentration of 2:10 is the maximum limit of the measurement of ibuprofen that can still be detected. Measurement of ibuprofen samples using EPK-rGO resulted in a percent recovery of 107.46%.

Keywords: Carbon paste electrode, reduced graphene oxide, ibuprofen, voltammetry

Topic: Environmental Chemistry and Engineering