Antimalarial Activity of Dogfruit (Pithecellbium jiringa) Skin Ethanol Extract on Plasmodium falciparum
Alfin Surya(a), Mega Irawan(b), Yulia Yesti(c*), Zaiyar(d)

a,b) Abdurrab University, Riau Ujung Street, Pekanbaru-

c) Fort De Kock University, Soekarno Hatta Street, Bukittinggi- *yuliayesti[at]fdk.ac.id

d)Pekanbaru High School of Technology, Dirgantara no.4 Street, Pekanbaru

Abstract

The Dogfruit skin is a solid waste and it causes problems when not properly handled. In addition, it pollutes the environment, which causes flooding over time. According to previous research, the Dogfruit skin has much potential because it contains flavonoid and polyphenolic compounds, which are antiseptic, and antioxidant. Therefore, this research aims to continue other activity tests such as the Antimalarial activity. The method used was cutting and drying Dogfruit skin in an oven at \( 60^{o} C \) then mashing and macerating it for 72 hours to extract the polar compounds. Furthermore, the antimalarial activity was tested by determining the \(IC_{50}\) value against Plasmodium falciparum (P. falciparum). The results showed that the highest and lowest percentage of P. falciparum growth inhibition occurred at a concentration of 100 and 0.01 \(\mu g/mL\), which reached 100 as well as 3.17%, respectively. Additionally, the probit analysis of \(IC_{50}\) ethanol extract of Dogfruit skin was 4.897 \(\mu g/mL\), which is a criterion for high potency (\( \le 5 \mu g/mL\) ).

Keywords: Antimalarial, Dogfruit Skin, Ethanol, Plasmodium falciparum

Topic: Natural Products and Biological Chemistry