The effect of dimefluthrin-based mosquito repellent activity on histopathological findings in the spleen and pancreas
Ary Andini, Asma Rubiah Rosyadahan, Shinta Nuryah Azizah, Devyana Dyah Wulandari, Ersalina Nidianti

Department of Medical Technology Laboratory, Faculty of Healthy, Universitas Nahdlatul Ulama Surabaya, Jl. Jemursari No. 51-57 Surabaya, East Java, Indonesia

Abstract

Mosquito repellent contains active substances that can prevent and paralyze mosquito activity. One of the active substances that play a role is dimefluthrin which has a negative effect on health if used for a long time. This study aims to analyze the effect of exposure to insect repellent on histopathological findings in the spleen and pancreas of Wistar rats. The study used Wistar rats which were divided into 4 groups, namely the control group and the intervention group including mosquito coils (dimefluthrin 0.031%), mosquito repellent liquid (dimefluthrin 0.014%), and insect repellent mat (dimefluthrin 0.566%) which were exposed for 8 hours in 20 days, respectively. Histopathological findings in the spleen and pancreas due to exposure to insect repellent seen in the electric mosquito repellent mat have the highest scores in cell degeneration and necrosis. The higher dimefluthrin content in insect repellent can affect the condition of the spleen and pancreas.

Keywords: mosquito- repellent- dimefluthrin- spleen- pancreas

Topic: Biomedical Science