The Relationship Between 25-Hydroxyvitamin D (25[OH]D) Levels with Serum Levels of Interleukin-4 (IL-4) and Interleukin-10 (IL-10) in Children with Mild and Moderate Asthma
Ade Habibi (1a), Wisnu Barlianto (1b)

1)Department of Child Health, Faculty of Medicine, University of Brawijaya, Indonesia

a) dr.adehabibi[at]gmail.com
b) wisnu_barlian[at]yahoo.com

Abstract

Asthma is a respiratory disease associated with chronic inflammation, hyperresponsiveness, and airway obstruction. Various cytokines may play a role in the pathophysiology of asthma, such as Th 2 cytokines (IL-4, IL-3, IL-5, and IL-13), which increase eosinophils and IgE levels that cause vasodilation, bronchial smooth muscle contraction, and mucus secretion, whereas IL-10 prevents chronic inflammation and tissue damage. Several hypotheses about nutrition are associated with asthma, including vitamin D levels, but this hypothesis is debatable. This research is cross-sectional, using consecutive sampling with 30 participants. Based on the relationship between vitamin D levels and average serum IL-4 levels, the groups with vitamin D deficiency, insufficiency, and sufficiency were 20.26 pg/ml, 2.08 pg/ml, and 1.89 pg/ml, respectively. Meanwhile, the average levels of IL-10 based on groups with vitamin D deficiency, insufficiency, and sufficiency were 5.14 pg/ml, 8.38 pg/ml, and 13.79 pg/ml, respectively. The results concluded that 25(OH)D levels have a significant negative relationship with serum IL-4 levels and a significant positive relationship with serum IL-10 levels in children with mild and moderate asthma.

Keywords: 25-Hydroxyvitamin D (25(Oh)D) Levels- Interleukin-4 (IL-4)- Interleukin-10 (IL-10)- Mild and Moderate Asthma.

Topic: Biomedical Science