Antidiabetic Effects of Spilanthes acemlla (Wall. ex DC.) C.B. Clarke ex Hook. flowers in silico studies
Muhammad Shofi*, Rifqi Hilman, and Daradjatul Aulia

Departement of Biology, Faculty of Mathematics and Natural Science, Malang Satte University, Malang 65145, East Java, Indonesia

Abstract

Context: One therapeutic approach to lowering blood sugar levels posprandial is to slow down or inhibit the absorption of glucose through inhibition of the carbohydrates hidrolitic enzyme such as &#945--amylase and &#945--glucosidase. In silico study can efficiently reduce the time and cost of such screening antidiabetic agent candidates.
Aims: To elucidate the molecular mechanisms underlying Antidiabetic Effects of Spilanthes acemlla (Wall. ex DC.) C.B. Clarke ex Hook. flowers in silico analysis.
Methods: Eight bioactive compounds of Spilanthes acemlla (Wall. ex DC.) C.B. Clarke ex Hook (spilanthol, amyrinester, stigmasterol, miricilic alcohol glycosides, sitosterol, saponins, acmelonate, and triterpenes were used for this study. The canonical smiles was investigated bioactive compound were retrieved from PubChem and Insert into (PASS) server to determine the biological activity using. Compounds were docked with several protein targets, including caspase 3, Bax and Bcl-2. Molecular docking was done by Pyrx 0.8 software and visualized by Discovery Studio software. The pharmacological properties of investigated bioactive compounds were analyzed using the SwissADME web server. Toxicity properties were anlyzed using Protox.
Results: The eight bioactive compounds of Spilanthes acemlla. flowers have Antidiabetic Effects properties. Results showed that various biological activities have a potential as Antidiabetic Effects of all investigated compounds including hypoglycemic effects. Based on SwissADME analysis known that most of the all investigated bioactive compounds showed optimum lipophilicity, size, polarity, solubility, and flexibility. candidate, so it needs to be studied further. Based on Protox analysis known that most of the investigated bioactive compounds showed in active hepatotoxicity, cytotoxicity and mutagen
Conclusions: The bioactive compounds of Spilanthes acemlla flowers might potentially modulate hypoglycemic effects

Keywords: Spilanthes acemlla, In silico, Antidiabetic effect

Topic: Bioinformatics