Patchouli (Pogostemon cablin Benth.): Progress on its In Vitro Cultivation and Pharmacological Perspectives
Anisa Esti Rahayu (a), Nurul Jadid (a*)

a) Department of Biology, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember Surabaya, 60111, Indonesia
*nuruljadid[at]bio.its.ac.id

Abstract

Patchouli (Pogostemon cablin Benth.), belonging to the family Lamiaceae, is a medicinal plant native to the Philippines and grows wild in many South Asian countries, including Indonesia. It is widely used in the pharmaceutical industry because it contains various bioactive compounds. These bioactive compounds include flavonoids, terpenoids, phytosterols, organic acids, lignins, glycosides, alcohols, pyrones, and aldehydes. The main bioactive compounds are patchouli alcohol, patchoulene epoxide, &#945--patchoulene, &#946--patchoulene, &#945--bulnesene, seychellene, norpatchoulenol, pogostone, eugenol, pogostol, and pachypodol. The pharmacological effects of these compounds include antioxidant, antimicrobial, antitumor, antidiabetic, anti-inflammatory, anti-oxidative, anti-peptic ulcer, anti-hypertensive, antiplatelet, antidepressant, antithrombotic, antimutagenic, antiemetic, effect on ischemia, immunoregulatory, analgesic, aphrodisiac, fibrinolytic, and cytotoxic activities. So, this medicinal plant is a leading commodity in the global market and has a high economic value. In vitro culture techniques have been widely used for the fast production of uniform, pathogen-free, and high-quality plants on a commercial scale. This review summarizes the recent progress in the plant in vitro cultivation and pharmacological aspects of patchouli and provides a reference for future studies focused on the mass production of patchouli plants.

Keywords: Bioactive compounds- In vitro culture- Pharmacology- Pogostemon cablin Benth

Topic: Biotechnology