Green Synthesis of Chalcones Derivatives Using FeCl3.6H2O as A Catalyst Under Solvent-Free Conditions
Indah Nur Pramesti a) and Zidni Akbarorrizki

Department Chemistry, Faculty of Mathematics and Science Education, Universitas Negeri Malang

a)Corresponding author: indahnur.pramesti.fmipa[at]um.ac.id

Abstract

Abstract. Chalcone is a precursor of a group of flavonoid and isoflavonoid compounds that are commonly found in plants in Indonesia. Chalcone compounds and their derivatives are reported to have antibacterial, antioxidant, anti-inflammatory, antimalarial, anticancer, antitumor, analgesic, and antipyretic activities. Chalcones can be synthesized through a Claisen-Smidth condensation reaction between aromatic aldehydes and ketones using an acid or base catalyst followed by a dehydration reaction. This study aimed to synthesize chalcone derivatives using eco-friendly non-toxic FeCl3.6H2O catalysts under solvent-free conditions. Our experiment was carried out to synthesize some chalcone derivatives at 100-140 oC by stirring process. In this study, the synthesis of chalcone derivatives was started with 10 mmol of various benzaldehyde (p-hydroxybenzaldehyde- p-methoxybenzaldehyde) and 10 mmol acetophenone in the presence of 0.1 mmol FeCl3.6H2O catalysts then the mixture was stirred for 20, 40 and 60 minutes. The product was then purified by recrystallization using ethanol. The purity of chalcones yielded was investigated by Thin Layer Chromatography (TLC) and melting point test while the structure was then characterized by UV-Vis and GC-MS analysis.

Keywords: Chalcones Derivatives, FeCl3.6H2O catalyst, Solvent-Free Conditions

Topic: Organic Chemistry