Study of Synthesis Hydrogel Poly(N-vinylcaprolactam-co-2-(dimethylamino)ethyl methacrylate) as a Responsive Polymer to pH and Temperature and Its Potential as an Active Material Delivery
Annisa Nurul Syabila, Noverra Mardhatillah Nizardo, Maria Lucia Ardhani Dwi Lestari

1) Department Chemistry, Mathematical and Natural Science Faculty, Universitas Indonesia, Depok, 16424,Indonesia.
2) Department Pharmaceutical Sciences, Pharmacy Faculty, Universitas Airlangga, Surabaya, 60115, Indonesia

Abstract

Hydrogel poly(N-vinylcaprolactam-co-(dimethylamino)ethyl metacrylate) (P(NVCL-co-DMAEMA)) as a polymer that is responsive to change in pH and temperature was successfully synthesized by free radical polymerization, using the azobisisobutironitrile (AIBN) initiator and N,N-methylenbisacrylamide (MBA) as crosslinker agent. Hydrogel was characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR and obtained the loss of peak absorption alkene at 1633 cm-1. The gelation percent increases and the equilibrium swelling value (ESV) decreases along with the addition of the DMAEMA monomer content. Hydrogel P(NVCL-co-DMAEMA) has the highest ESV value at pH 2 and room temperature. Based on the swelling test at various pH and temperatures, the hydrogel with the largest ESV was obtained in the composition 30 percent mole of the NVCL monomer and the 70 percent mole of the DMAEMA monomer. The influence of the concentration of crosslinker agents was studied by varying from 2, 4 and 8 percent of the total mole monomer. The highest ESV results were obtained from hydrogels with a crosslinker agent content of 2 percent monomer mole. Hydrogel also has the potential as a active material delivery with an encapsulation ability of 54.4521 percent and optimum release at pH 6.8 and a temperature of 37 degrees celcius of 29.07 percent.

Keywords: pH responsive hydrogel- temperature responsive hydrogel- poly(N-vinylcaprolactam)- poly(2-(dimethylamino)ethylmethacrylate)- poly(N-vinylcaprolactam-co-(dimethylamino)ethylmetacrylate.

Topic: Organic Chemistry