Synthesis of 3-N-Methyl Derivative of Phenytoin by Potassium Carbonate
Arif Fadlan, Aji Purnama Putra,and Fahimah Martak

Institut Teknologi Sepuluh Nopember

Abstract

Phenytoin, a heterocyclic compound with 1,3-diazole backbone, blocks the sodium channel and has been used as antiepileptic drug with partial and general seizures. Phenytoin has been further developed by modification with alkyl, aryl, and halogen substituents. Previous studies reported that alkylation can provide compounds with promising activity and the presence of methyl group increases the biological activities. Thus, the synthesis of 3-N-methyl derivative of phenytoin is described herein. The derivative was synthesized in good yield from phenytoin and iodomethane with potassium carbonate in acetonitrile under reflux. NMR, MS, infrared analysis was performed for structure elucidation of synthesized compounds.

Keywords: 1,3-diazole-Methyl- Phenytoin.

Topic: Organic Chemistry